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KMID : 0613820130230020282
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Journal of Life Science
2013 Volume.23 No. 2 p.282 ~ p.289
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Effects of Makgeolli and Makgeolli precipitate on Hepatotoxicity and Serum Lipid Content in Rats
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Kim Bo-Kyung
Kang Min-Sook
Jeon Myeong-Jeong
Lee Sang-Hyeon
Kim Mi-Hyang
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Abstract
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This study was conducted to investigate the effect of Makgeolli and Makgeolli precipitate on hepatotoxity and the serum lipid content in rats. First, we investigated the effect of Makgeolli and ethanol on the progress of alcoholic fatty liver. The effect of Makgeolli precipitate on carbon tetrachloride ($CCl_4$ 수식 이미지)-induced hepatotoxicity in the rats was then studied. Indicators of the health status of the experimental period, the body weight gain in ethanol-treated group tended to be lower than those in the control and the Makgeolli-treated groups. The weight of the liver tissue decreased significantly following the administration of ethanol. However, this was not seen following the administration of Makgeolli. The activities of serum aspartate transaminase (AST) and alanine transaminase (ALT) were decreased in the Makgeolli group compared to the ethanol group. Serum cholesterol concentrations increased in the ethanol group, but decreased in the Makgeolli-treated group to an equal volume of the ethanol-treated group. The serum HDL-cholesterol content was significantly higher in the Makgeolli group than in the ethanol group. Analysis of the impact of the Makgeolli precipitate on toxicity induced by CCI₄ in the liver showed that the CCI₄ treatment significantly increased the activities of serum ALT and AST. However, the levels of cholesterol and triglyceride in serum were decreased. The CCI₄ treatment increased the activities of AST and ALT. However, the raw Makgeolli precipitate decreased their activities. Moreover, raw Makgeolli precipitate significantly reduced the CCI₄-induced elevation of serum lipids more than heated Makgeolli precipitate. These results suggest that raw Makgeolli precipitate may exert a protective effect against CCI₄-induced liver injury by preventing lipid peroxidation.
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KEYWORD
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Makgeolli, Makgeolli prepicitate, serum lipids, hepatotoxicity, rats
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